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Roche manufactured Valium for the treatment of anxiety disorders, a derivative of benzodiazepine. It is useful for treating anxiety, insomnia, muscle spasms and some types of epilepsy. Valium (Diazepam) is also used to medical procedures such as endoscopy to minimize tension and anxiety because it possesses anticonvulsant, skeletal muscle relaxant, anxiolytic, amnestic and sedative properties
Approved for use in 1963 and is five times more effective than the first benzodiazepine (chlordiazepoxide) developed, Valium has shoot up its sales more than the first drug developed.
It has been the most prescribed benzodiazepine and is used to treat a wide range of medical conditions. For that matter, the World Health Organization has listed Diazepam as a core medicine in its Essential Drug List.
Common side effects of Valium are as follows: • drowsiness • impaired coordination, motor functions, and balance • fatigue and dizziness • depression • anterograde amnesia • reflex tachycardia
The above symptoms are present with most benzodiazepines. Confusion, nervousness, nausea, diplopia, constipation, headache, hypotension, dysarthria, incontinence, jaundice, changes in sex drive and in salivation, slurring of speech, tremor, rash, urinary retention, irritability, vertigo, muscle cramps, insomnia are its unusual side effects. Valium must be withdrawn if any of these side effects develop.
Pharmacological interactions must be given attention when prescribing Valium with other medications. Special concern must be taken with narcotics, antidepressants, barbiturates and phenotihiazines. Salty foods can slow down the absorption and elimination of diazepam thereby increasing drug activity and levels. Foods that acidify urine, nonetheless, can lead to a faster absorption and elimination of diazepam and therefore decrease drug activity and levels. Valium also maximizes the depressive effects of alcohol, narcotics, other sedatives/hypnotics and muscle relaxants which can lead to increased risk of psychological dependence. If this happens, treatment must be discontinued especially if there are any signs of abuse or dependence development.
